SF has been explored to develop new materials such as porous materials, scaffolds, wound dressings, hydrogels, nano-particles and as a substrate in optics and sensors ( Kim et al., 2005 Nogueira et al., 2011 Wenk et al., 2011 Calamak et al., 2014 Li et al., 2017 Wang et al., 2020). It has good mechanical properties with high tensile strength and high thermal resistance with a temperature of degradation close to 300РІВРЉ ( Kundu et al., 2013 Koh et al., 2015). Silk fibroin is a protein produced by arthropods like spiders, mites, bees and silkworms, the last one is more used due to the facility of domestication ( Kundu et al., 2013), the main producer worldwide is Bombyx mori silkworm ( Koh et al., 2015). Despite that, the commercialization of these products is not a reality due to the complexity of the system formed by these polymers. Most of the works with these two polymers explore the potential of the blends as a biomaterial due to their characteristics such as biocompatibility, biodegradability and low toxicity ( de Moraes and Beppu, 2013 de Moraes et al., 2014 Ming and Zuo, 2014 Zhang et al., 2015 Wang et al., 2016). The Flory-Huggins parameters of interaction of polymer-solvent and polymer-polymer were estimated using the extended equation and data of phase equilibrium, their values indicates the partial miscibility of the polymers.Р”В«lends of Silk fibroin (SF) and sodium alginate (SA) have been studied since the beginning of the 90РІР‚в„ўs years ( Liang and Hirabayashi, 1992). After phase separation, two phases were identified, one rich in SF and other rich in SA.

This study explored blends with a different initial composition of SF, SA, and water (WA) at 25РІВРЉ and neutral pH. Phase separation is observed, therefore, the thermodynamic analysis of this system is important to predict the final state and composition of this blends. One of the strategies to improve the properties of these products is to prepare blends with them, which are partially miscible. Silk fibroin (SF) and sodium alginate (SA) are natural polymers used to produce biomaterials. 2Department of Chemical Engineering, Federal University of SР“Р€o Paulo, Diadema, Brazil.1School of Chemical Engineering, University of Campinas, Campinas, Brazil.Laise Maia Lopes 1РІР‚В , Mariana Agostini de Moraes 2РІР‚В and Marisa Masumi Beppu 1*РІР‚В

Max and min solvent ternary diagram